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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
44.85
Human Site:
Y522
Identified Species:
70.48
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
Y522
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Chimpanzee
Pan troglodytes
XP_528129
863
96543
Y522
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
Y588
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
Y521
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Rat
Rattus norvegicus
NP_387500
862
96552
Y521
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
Y522
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Chicken
Gallus gallus
XP_424376
859
96866
Y518
S
K
S
Q
L
L
Q
Y
V
Y
N
L
V
P
R
Frog
Xenopus laevis
P30664
863
97105
Y522
S
K
S
Q
L
L
Q
Y
V
F
N
L
V
P
R
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
E426
E
Q
K
L
F
T
K
E
R
V
A
L
L
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
Y524
S
K
S
Q
M
L
Q
Y
V
F
N
L
V
P
R
Honey Bee
Apis mellifera
XP_624670
636
71159
A312
L
I
P
Q
M
R
E
A
Y
F
K
C
S
I
C
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
L435
M
E
G
G
A
M
V
L
A
D
G
G
V
V
C
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
Y569
S
K
S
Q
L
L
Q
Y
V
H
N
L
V
P
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
V392
L
L
K
H
I
I
N
V
A
P
R
G
V
Y
T
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
Y580
S
K
S
Q
I
L
Q
Y
V
H
K
I
T
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
93.3
6.6
N.A.
86.6
6.6
6.6
93.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
26.6
N.A.
100
26.6
20
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
7
14
0
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
14
% C
% Asp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% D
% Glu:
7
7
0
0
0
0
7
7
0
0
0
0
0
0
7
% E
% Phe:
0
0
0
0
7
0
0
0
0
20
0
0
0
0
0
% F
% Gly:
0
0
7
7
0
0
0
0
0
0
7
14
0
0
0
% G
% His:
0
0
0
7
0
0
0
0
0
14
0
0
0
0
0
% H
% Ile:
0
7
0
0
14
7
0
0
0
0
0
7
0
7
0
% I
% Lys:
0
74
14
0
0
0
7
0
0
0
14
0
0
7
0
% K
% Leu:
14
7
0
7
60
74
0
7
0
0
0
74
7
0
0
% L
% Met:
7
0
0
0
14
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
67
0
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
7
0
0
0
74
0
% P
% Gln:
0
7
0
80
0
0
74
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
0
7
0
7
0
0
0
74
% R
% Ser:
74
0
74
0
0
0
0
0
0
0
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
7
% T
% Val:
0
0
0
0
0
0
7
7
74
7
0
0
80
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
74
7
47
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _